In an open access publication involving projects A02 and A03, two of our doctoral researchers, Rocco (AG Holger Gohlke) and Matea (AG Jaeger) are first authors. In a collaborating team, they  unravel "Molecular Mechanisms Underlying Medium-Chain Free Fatty Acid-Regulated Activity of the Phospholipase PlaF from Pseudomonas aeruginosa".
The membrane-bound phospholipase A1 from Pseudomonas aeruginosa is a potential drug target. PlaF remodels membrane glycerophospholipids, influencing virulence-associated signaling. Medium-chain free fatty acids, products of PlaF action, inhibit its activity. Molecular simulations, free energy computations, in vitro and in vivo assays uncover how fatty acids control PlaF.

Gentile R, Modric M, Thiele B, Jaeger K-E, Kovacic F, Schott-Verdugo S, Gohlke H
Molecular Mechanisms Underlying Medium-Chain Free Fatty Acid-Regulated Activity of the Phospholipase PlaF from Pseudomonas aeruginosa.
JACS Au (2024) 4(3), 958-973; doi.org/10.1021/jacsau.3c00725